Mark Fiore

I've been following Mark Fiore's work for some time now in Salon--he does Flash-based political cartoons, and does them well, using temporal sequencing/looping, animation, and audio to great effect. The tinny background music, for example, is the aural complement to the jerky stop-motion animation, which is itself a manufactured aesthetic--but one that seems just right, demonstrating Fiore's empathy for the medium. He also has an eye for detail: for example, watch the eyes of the characters in 3/26/03 "Congratulations," or the flies buzzing around the goat.

Other new media humorists? (Yup, of course I know about Scott McCloud's pioneering stuff.)